NVIDIA Blackwell Slashes AI Inference Costs by 10x as Providers Report Major Cost Reductions

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Inference providers including Baseten, DeepInfra, Fireworks AI and Together AI report 4x to 10x reductions in AI inference costs using NVIDIA Blackwell with open source models. The dramatic improvements stem from combining Blackwell's hardware capabilities with optimized software stacks and low-precision formats like NVFP4, transforming economics across healthcare, gaming and customer service applications.

NVIDIA Blackwell Drives Dramatic Reductions in AI Inference Costs

AI inference costs have dropped by up to 10x as leading inference providers deploy NVIDIA Blackwell platform with open source models, according to production data released by NVIDIA. Baseten, DeepInfra, Fireworks AI, and Together AI report cost reductions ranging from 4x to 10x compared with the previous NVIDIA Hopper platform, transforming the economics of scaling AI applications across industries

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. The improvements address a critical business challenge: whether companies can afford to scale AI interactions as demand grows. Tokenomics—the cost per token—has become the determining factor in whether AI deployments remain viable at scale.

The cost reductions emerge from combining three elements rather than hardware alone. NVIDIA Blackwell delivers baseline performance improvements, but reaching 4x to 10x reductions requires pairing the platform with optimized software stacks and switching to open source models that now match frontier-level intelligence

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. "Performance is what drives down the cost of inference," Dion Harris, senior director of HPC and AI hyperscale solutions at NVIDIA, told VentureBeat. "What we're seeing in inference is that throughput literally translates into real dollar value and driving down the cost."

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Source: VentureBeat

Source: VentureBeat

Healthcare Applications Achieve 10x Reduction in Token Costs

Sully.ai cut healthcare AI inference costs by 90%—representing a 10x reduction—while improving response times by 65% for critical workflows like generating medical notes

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. The company develops AI employees that handle routine tasks like medical coding and note-taking, returning time to physicians previously lost to data entry. Sully.ai switched from proprietary models to open source models running on Baseten's Model API, which deploys models like gpt-oss-120b on NVIDIA Blackwell GPUs

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. Baseten used the low-precision NVFP4 data format, the TensorRT-LLM library and the NVIDIA Dynamo inference framework to deliver optimized inference. The platform has now returned over 30 million minutes to physicians, time previously consumed by manual tasks

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Gaming and Customer Service See 4x to 6x Cost Efficiencies

Latitude reduced gaming inference costs by 4x for its AI Dungeon platform and upcoming Voyage role-playing game by running large Mixture-of-Experts models on DeepInfra's Blackwell-powered infrastructure

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. Cost per million tokens dropped from 20 cents on NVIDIA Hopper to 10 cents on Blackwell, then to just 5 cents after adopting Blackwell's native NVFP4 low-precision format

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. Hardware improvements alone delivered 2x gains, but reaching 4x required the precision format change

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. Every player action in Latitude's platform triggers an inference request, making cost savings essential as engagement scales.

Decagon achieved 6x cost reduction per query for AI-powered voice customer support by running its multimodel stack on Together AI's Blackwell infrastructure, maintaining response times under 400 milliseconds even when processing thousands of tokens per query

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. Low latency proves critical for voice interactions where delays cause users to disconnect or lose trust. Sentient Foundation reported 25% to 50% better cost efficiency for agentic chat platforms using Fireworks AI's Blackwell-optimized inference stack, processing 5.6 million queries in a single week during its viral launch

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Extreme Co-Design Approach Enables Lower Per-Token Costs

NVIDIA's extreme co-design approach combines hardware architecture with software optimization to achieve infrastructure efficiency gains

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. The GB200 NVL72 configuration uses 72 chips coupled with 30TB of fast shared memory to optimize expert parallelism in Mixture-of-Experts architectures, ensuring token batches split and scatter across GPUs efficiently

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. MoE models activate different specialized sub-models based on input, benefiting from Blackwell's NVLink fabric that enables rapid communication between experts

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Source: NVIDIA

Source: NVIDIA

Precision formats show the clearest impact on cost savings. NVFP4 reduces the number of bits required to represent model weights and activations, allowing more computation per GPU cycle while maintaining accuracy

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. The software stack integration with tools like TensorRT-LLM and Dynamo creates additional performance improvements beyond hardware alone. Recent MIT research found that infrastructure and algorithmic efficiencies are reducing inference costs for frontier-level performance by up to 10x annually

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. Businesses now face counterintuitive economics: reducing AI inference costs requires investing in higher-performance infrastructure because throughput improvements translate directly into lower per-token costs. As enterprises scale AI from pilot projects to millions of users, these cost reductions determine which applications remain economically viable.

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