Recursion Pharmaceuticals Reports Q1 2025 Results: AI-Driven Strategy Reshapes Pipeline and Partnerships

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Recursion Pharmaceuticals, a clinical-stage TechBio company, announces Q1 2025 financial results and business updates, highlighting its AI-driven approach to drug discovery and development, strategic pipeline adjustments, and progress in key partnerships.

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Recursion's AI-Driven Strategy Reshapes Drug Discovery Landscape

Recursion Pharmaceuticals (NASDAQ: RXRX), a leading clinical-stage TechBio company, has reported its first quarter 2025 financial results and business updates, showcasing the impact of its AI-driven approach on drug discovery and development 12. The company's decade-long investment in artificial intelligence is now driving a data-led portfolio strategy, prioritizing high-potential programs to accelerate better treatments for patients.

Strategic Pipeline Adjustments

Recursion has implemented a focused R&D strategy, advancing a streamlined portfolio of over five clinical and preclinical programs in oncology and rare diseases 1. This strategic shift has led to the deprioritization of three clinical programs and one preclinical program following a data-driven review. The company's Chief R&D Officer and Chief Commercial Officer, Najat Khan, emphasized that this portfolio evolution reflects Recursion's commitment to areas of high unmet need where they believe they can have the greatest impact 12.

Key Program Updates

REC-4881 (MEK1/2) for Familial Adenomatous Polyposis (FAP)

Preliminary data from the Phase 1b/2 TUPELO study showed promising results:

  • Median 43% reduction in polyp burden at week 13 (n=6 patients)
  • 50% of patients achieved ≥1-point improvement in Spigelman stage
  • Generally consistent safety profile with prior MEK1/2 inhibitors 1

REC-7735 (PI3Kα H1047R) for Breast Cancer

  • Candidate profiling ongoing with DC nomination expected in 2H25
  • Showed dose-dependent tumor regression in preclinical models
  • Potential for improved efficacy and tolerability compared to standard-of-care 1

REV102 (ENPP1) for Hypophosphatasia (HPP)

  • IND-enabling studies ongoing with Phase 1 initiation expected in 2H26
  • Improved survival in early-onset HPP model and bone defects in late-onset model
  • First-in-class potential for adult-onset HPP 1

Partnership Milestones

Recursion's collaborations with major pharmaceutical companies have yielded significant progress:

  1. Sanofi Collaboration:

    • Achieved fourth milestone, generating $7 million
    • Identified orally active small-molecule lead with best-in-class potential in autoimmune diseases
    • Total cash inflows of $130 million to date, with potential for over $300 million in additional milestone payments 12
  2. Roche and Genentech Collaboration:

    • Built five phenomaps from over one trillion iPSC-derived cells and 100 billion GI Oncology relevant cells
    • Integrated high-throughput screens with detailed cell measurements to inform AI/ML models
    • Focused on leveraging Recursion OS to identify novel programs in GI Oncology and Neuroscience 2

Platform and Financial Updates

Recursion has implemented synergies and streamlined operations while maintaining core capabilities, extending its cash runway until mid-2027 1. The company's CFO, Ben Taylor, highlighted the benefits of the recent business combination with Exscientia, allowing for more efficient operational goals and flexibility in uncertain market conditions 2.

Looking Ahead

As Recursion continues to leverage its Recursion OS platform and AI capabilities, the company is poised to lead the transformative shift in drug discovery. With a focused portfolio, strategic partnerships, and a strong financial position, Recursion aims to decode biology and radically improve lives through its innovative TechBio approach 12.

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