Europe's Uneven Progress in Biliary Atresia Screening: AI and Digital Tools Offer Hope

Europe faces uneven progress in biliary atresia screening efforts

Chinese Academy of SciencesJun 20 2025 Published (DOI: 10.1136/wjps-2025-001026) on May 12, 2025, in World Journal of Pediatric Surgery, researchers from Geneva University Hospitals conducted the first scoping review of BA screening efforts across Europe. Their findings reveal a patchwork landscape: while countries like Switzerland, France, and Germany have introduced national SCC programs, most others lag behind or rely solely on localized pilots. This review highlights both systemic inertia and promising technologies -- such as AI-enabled apps -- that could bridge the gap in diagnosis and care, advocating for Europe to rethink and revitalize its approach to neonatal liver screening. This review assessed a wide range of data -- from published literatures to digital health tools -- on three major screening strategies: SCC, serum bilirubin testing, and biochemical profiling. Switzerland was the first country in Europe to launch a national SCC program, reducing the median age of surgery and eventually integrating the card into newborn health booklets. France followed through a parent-led advocacy campaign, while Germany only recently mandated SCC use nationwide. Elsewhere, efforts remain sporadic. Studies consistently show SCC's effectiveness improves dramatically when accompanied by clear referral guidance. Yet many pediatricians still resist its use, citing workload and psychological concerns. Meanwhile, the UK has led research on bilirubin screening, showing exceptional accuracy -- but has failed to move from research to policy due to logistical and financial barriers. Recent breakthroughs such as Italy's PopòApp and Germany's AI-powered stool image analysis show strong potential for improving accuracy and scalability. Together, these insights suggest that Europe has both the tools and the knowledge -- but not yet the will -- to implement widespread BA screening. Europe has no shortage of expertise, evidence, or technology -- what's missing is coordinated action. We've seen how something as simple as a color card can shift outcomes dramatically. Add digital tools and clinical buy-in, and we could revolutionize early diagnosis for thousands of infants. But time is of the essence -- each delay costs lives." Professor Barbara E. Wildhaber, senior author of the study A unified European strategy could turn the tide against BA-related infant mortality. Combining SCC with digital apps and AI can provide low-cost, high-reach solutions for families and frontline clinicians. Serum bilirubin testing, though more expensive, captures a wider spectrum of liver diseases and could complement SCC-based programs. Countries may benefit most from hybrid screening models tailored to their healthcare infrastructure. Crucially, any technical rollout must be paired with education, awareness, and strong political advocacy. With the right alignment of tools, policy, and public will, Europe can catch up -- and catch the infants who need help most. Chinese Academy of Sciences Journal reference: Wildhaber, B. E. & Calinescu, A. M., (2025). European strategies in the screening of biliary atresia: a scoping review. World Journal of Pediatric Surgery. doi.org/10.1136/wjps-2025-001026.

From Cards to Code: Reviving Europe's Battle Against Biliary Atresia | Newswise

Newswise -- Published (DOI: 10.1136/wjps-2025-001026) on May 12, 2025, in World Journal of Pediatric Surgery, researchers from Geneva University Hospitals conducted the first scoping review of BA screening efforts across Europe. Their findings reveal a patchwork landscape: while countries like Switzerland, France, and Germany have introduced national SCC programs, most others lag behind or rely solely on localized pilots. This review highlights both systemic inertia and promising technologies -- such as AI-enabled apps -- that could bridge the gap in diagnosis and care, advocating for Europe to rethink and revitalize its approach to neonatal liver screening. This review assessed a wide range of data -- from published literatures to digital health tools -- on three major screening strategies: SCC, serum bilirubin testing, and biochemical profiling. Switzerland was the first country in Europe to launch a national SCC program, reducing the median age of surgery and eventually integrating the card into newborn health booklets. France followed through a parent-led advocacy campaign, while Germany only recently mandated SCC use nationwide. Elsewhere, efforts remain sporadic. Studies consistently show SCC's effectiveness improves dramatically when accompanied by clear referral guidance. Yet many pediatricians still resist its use, citing workload and psychological concerns. Meanwhile, the UK has led research on bilirubin screening, showing exceptional accuracy -- but has failed to move from research to policy due to logistical and financial barriers. Recent breakthroughs such as Italy's PopòApp and Germany's AI-powered stool image analysis show strong potential for improving accuracy and scalability. Together, these insights suggest that Europe has both the tools and the knowledge -- but not yet the will -- to implement widespread BA screening. "Europe has no shortage of expertise, evidence, or technology -- what's missing is coordinated action," said Professor Barbara E. Wildhaber, senior author of this study. "We've seen how something as simple as a color card can shift outcomes dramatically. Add digital tools and clinical buy-in, and we could revolutionize early diagnosis for thousands of infants. But time is of the essence -- each delay costs lives." A unified European strategy could turn the tide against BA-related infant mortality. Combining SCC with digital apps and AI can provide low-cost, high-reach solutions for families and frontline clinicians. Serum bilirubin testing, though more expensive, captures a wider spectrum of liver diseases and could complement SCC-based programs. Countries may benefit most from hybrid screening models tailored to their healthcare infrastructure. Crucially, any technical rollout must be paired with education, awareness, and strong political advocacy. With the right alignment of tools, policy, and public will, Europe can catch up -- and catch the infants who need help most. World Journal of Pediatric Surgery is an international open access journal publishing original researches, reviews, perspectives and short reports on all aspects of pediatric surgery. The journal is particularly interested in interdisciplinary studies including, but not limited to, minimally invasive surgery, robotic surgery, precision surgery, artificial intelligence, new materials and medical instruments.