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AI tool grounded in evidence-based medicine outperformed other AI tools -- and most doctors- on USMLE exams
Achieving higher scores on the USMLE than most physicians and all other AI tools so far, Semantic Clinical Artificial Intelligence (SCAI, pronounced "Sky") has the potential to become a critical partner for physicians, says lead author Peter L. Elkin, MD, chair of the Department of Biomedical
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Clinical AI tool scores highest yet on the United States Medical Licensing Exam
University at BuffaloApr 22 2025 A powerful clinical artificial intelligence tool developed by University at Buffalo biomedical informatics researchers has demonstrated remarkable accuracy on all three parts of the United States Medical Licensing Exam (Step exams), according to a paper published
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An AI tool grounded in evidence-based medicine outperforms other AI tools -- and most doctors -- on USMLE exams
A powerful clinical artificial intelligence tool developed by University at Buffalo biomedical informatics researchers has demonstrated remarkable accuracy on all three parts of the United States Medical Licensing Exam (Step exams), according to a paper published in JAMA Network Open. Achieving
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An AI tool grounded in evidence-based medicine outperformed other AI tools - and most doctors - on USMLE exams
BUFFALO, N.Y. -- A powerful clinical artificial intelligence tool developed by University at Buffalo biomedical informatics researchers has demonstrated remarkable accuracy on all three parts of the United States Medical Licensing Exam (Step exams), according to a paper published today (April 22)
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A new AI tool called SCAI, developed by University at Buffalo researchers, has achieved unprecedented accuracy on the United States Medical Licensing Exam, outperforming most physicians and other AI models.

Researchers at the University at Buffalo have developed a groundbreaking clinical artificial intelligence tool called Semantic Clinical Artificial Intelligence (SCAI), which has demonstrated exceptional performance on the United States Medical Licensing Exam (USMLE). The study, published in JAMA Network Open, reveals that SCAI outperformed most physicians and all other AI tools tested so far
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.SCAI achieved remarkable scores on all three parts of the USMLE, with its most advanced version scoring 95.2% on Step 3 of the exam. In comparison, a GPT4 Omni tool scored 90.5% on the same test
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. This performance demonstrates SCAI's potential to become a critical partner for physicians in clinical decision-making.Unlike traditional AI tools that rely on statistical associations in online data, SCAI employs complex semantic reasoning. Dr. Peter L. Elkin, lead author and chair of the Department of Biomedical Informatics at the University at Buffalo, explains that SCAI can "add to your decision-making and thinking based on its own reasoning"
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.SCAI's impressive capabilities stem from its vast knowledge base, which includes:
This comprehensive approach allows SCAI to reason similarly to how medical professionals think when practicing evidence-based medicine
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.The researchers believe SCAI has the potential to:
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While SCAI's capabilities are impressive, Dr. Elkin emphasizes that its role will be to augment, not replace, physicians. He states, "Artificial intelligence isn't going to replace doctors, but a doctor who uses AI may replace a doctor who does not"
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.The development of SCAI represents a significant advancement in clinical AI, potentially revolutionizing medical education, decision-making, and patient care. As AI tools like SCAI continue to evolve, they may become indispensable partners for healthcare professionals, enhancing the quality and efficiency of medical practice across various specialties.
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