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Inside OpenAI's big play for science
An exclusive conversation with Kevin Weil, head of the firm's new AI for Science team. In the three years since ChatGPT's explosive debut, OpenAI's technology has upended a remarkable range of everyday activities at home, at work, in schools -- anywhere people have a browser open or a phone out,
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Scientists are sending millions of questions to AI, speeding up research
AI contributes to solutions in mathematics, confirmed by human experts * OpenAI claims 8.4 million weekly messages are sent about advanced science and mathematics * GPT-5.2 models can follow long reasoning chains and verify results independently * AI accelerates routine research tasks like
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Exclusive: OpenAI wants to be a scientific research partner
Why it matters: OpenAI argues that AI can make scientists more productive by upping the amount of research that can get done, ultimately leading to more life-saving breakthroughs. By the numbers: Per OpenAI's report, an internal analysis of a random sample of anonymized ChatGPT conversations from
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ChatGPT Is Being Used as a Scientific Collaborator, Says OpenAI
AI engagement in science spans maths, physics, biology and chemistry OpenAI has outlined a growing role for artificial intelligence (AI) systems as collaborators in scientific research, arguing that tools like ChatGPT can help researchers make progress on complex problems across disciplines
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OpenAI has established a new AI for Science team led by Kevin Weil to help scientists accelerate research across mathematics, physics, chemistry, and biology. The company reports that 1.3 million weekly users now send 8.4 million messages on advanced science topics, representing 47% growth over the past year. GPT-5.2 achieves 92% accuracy on graduate-level benchmarks, though questions remain about long-term validation.
OpenAI has launched a new division called OpenAI for Science, marking an explicit push to position its large language models as partners in scientific research. Led by Kevin Weil, a vice president who joined the company as chief product officer after stints at Twitter and Instagram, the team was announced in October 2025 and aims to explore how AI tools for researchers can support work across mathematics, physics, chemistry, and biology
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. Weil, who abandoned a particle physics PhD at Stanford for Silicon Valley, frames the initiative as central to OpenAI's mission of building artificial general intelligence that benefits humanity. "Maybe the biggest, most positive impact we're going to see from AGI will actually be from its ability to accelerate scientific research," he told MIT Technology Review1
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Source: TechRadar
Internal analysis of anonymized ChatGPT conversations from January to December 2025 reveals substantial adoption among researchers. Average weekly message counts on advanced science and mathematics topics grew nearly 47% year-over-year, climbing from 5.7 million to approximately 8.4 million messages
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. As of January 2026, nearly 1.3 million weekly users discuss advanced topics in scientific research with the AI, spanning graduate and research-level work3
. Computer science, data science, and AI represent the most common domains, though engagement extends to computational chemistry, particle physics, and structural equation models3
. Kevin Weil emphasized that "more researchers are using advanced reasoning systems to make progress on open problems, interpret complex data, and iterate faster in experimental work"3
.The company attributes growing adoption to significant improvements in GPT-5's capabilities for complex problem-solving. On GPQA, an industry benchmark with over 400 multiple-choice questions testing PhD-level knowledge in biology, physics, and chemistry, GPT-5.2 reportedly scores 92% compared to GPT-4's 39% and a human-expert baseline of around 70%
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. The model achieved gold-level results at the 2025 International Mathematical Olympiad and demonstrated partial success on the FrontierMath benchmark2
. GPT-5.2 models can sustain long reasoning chains, verify results independently, and operate with formal proof systems like Lean2
. OpenAI claims the models contributed to solutions connected to open Erdős problems, with human mathematicians confirming the results2
.Most scientists and engineers use ChatGPT for writing and communication tasks, while a smaller share employ it for rigorous analysis and calculations
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. Researchers increasingly turn to the system as a scientific collaborator for routine, time-consuming activities including coding, literature synthesis, data interpretation, simulation support, and experiment planning4
. In chemistry and biology, hybrid approaches pair general-purpose large language models with specialized tools such as graph neural networks and protein structure predictors2
. Physics laboratories reportedly use AI to integrate simulations, experimental logs, documentation, and control systems while supporting theoretical exploration2
. OpenAI cites case studies where AI shortened protein design timelines from years to months at RetroBioSciences2
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Source: Axios
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Despite the momentum, OpenAI enters a space where Google DeepMind has operated for years with groundbreaking scientific models such as AlphaFold and AlphaEvolve
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. When Demis Hassabis, Google DeepMind's CEO and cofounder, discussed his firm's AI-for-science team in 2023, he stated: "This is the reason I started DeepMind ... In fact, it's why I've worked my whole career in AI"1
. OpenAI's timing reflects recent advances in reasoning systems that have elevated AI capabilities beyond SAT-level performance to graduate-level work1
. While the models do not generate entirely new mathematical theories, they recombine known ideas and identify connections across fields, which speeds up formal verification and scientific discovery2
.Independent validation of OpenAI's reported gains remains limited
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. Questions persist about how well these results hold up over time, how broadly they apply, and whether the reported gains translate into lasting scientific advances2
. OpenAI argues that scientific progress supports medicine, energy systems, and public safety, yet research often advances slowly and requires substantial labor, with projects such as drug development taking more than a decade2
. The company is urging policymakers to enhance science and research uses of AI, including scaling AI skilling, opening up data and frontier AI access to more people, and modernizing AI infrastructure3
. For researchers watching this space, the key question is whether AI can move from handling routine tasks to contributing genuine insights that reshape how scientific discovery unfolds.Summarized by
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