HPE expands AI infrastructure portfolio with Nvidia to power autonomous agents at enterprise scale

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HPE unveiled major updates to its AI infrastructure portfolio at Discover in Las Vegas, integrating Nvidia's Vera CPU and Agent Toolkit into its Private Cloud AI platform. The enhancements include confidential computing across all AI Factory solutions, Juniper networking integration, and governance tools designed to help enterprises deploy thousands of autonomous AI agents securely.

HPE AI Infrastructure Gets Major Upgrade for Agentic AI

Hewlett Packard Enterprise unveiled sweeping updates to its HPE AI infrastructure portfolio at its Discover conference in Las Vegas, positioning itself as a full-stack provider for enterprises moving agentic AI from proof of concept to production

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. CEO Antonio Neri framed the shift as a fundamental transformation where enterprises are no longer just operators of technology but designers of outcomes, emphasizing that "architecting for AI starts with your network"

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Source: SiliconANGLE

Source: SiliconANGLE

The announcements span the company's entire AI infrastructure portfolio, including HPE Private Cloud AI, HPE AI Factory at-scale, and Sovereign AI Factory products. HPE's EVP and CTO Fidelma Russo told The Register that the company has made "significant progress around our AI factory portfolio" to help customers with their transformation to an agentic AI infrastructure

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Nvidia Vera CPU and Agent Toolkit Integration

A centerpiece of the expansion is the HPE ProLiant Compute DL394 Gen12 server featuring the Nvidia Vera CPU, expected to be available in early 2027 with HPE Private Cloud AI

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. The Vera CPU represents the first processor built specifically for autonomous AI agents, designed to handle the tool calls, orchestration, and real-time data processing required across the agent loop with deterministic, low-latency performance

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The New York Stock Exchange, in collaboration with Redpanda and HPE, is an early enterprise customer exploring the Vera CPU with the new ProLiant server

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. The Vera CPU is part of the broader Nvidia Vera Rubin platform, which is ramping into full production with the Nvidia Vera Rubin NVL72 rack-scale system available from HPE. The company is also bringing the HPE Compute XD700 built on Nvidia HGX Rubin NVL8, supporting up to 128 Rubin GPUs per rack

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HPE Private Cloud AI will now ship with the Nvidia Agent Toolkit, which includes Nvidia Nemotron models, the Nvidia OpenShell secure runtime, and NemoClaw blueprints

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. These components function as an agentic AI operating system for monitoring agent behavior, enforcing governance frameworks, and safely building and running autonomous, long-running multi-agent systems

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Source: NVIDIA

Source: NVIDIA

Confidential Computing and Security Enhancements

Nvidia Confidential Computing is now available across the entire HPE AI Factory through HPE Services, including HPE AI Factory at Scale, HPE Sovereign AI Factory, and HPE Private Cloud AI

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. This capability protects models and private data during execution for on-premises and sovereign deployments, establishing a chain of trust through cryptographic attestation and encryption at every stage

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The HPE ProLiant Compute DL380a achieved certification as part of the Nvidia-Certified Systems for Nvidia Confidential Computing program, validating robust application performance with confidential computing while maintaining optimal Nvidia acceleration

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. Across HPE AI Factory solutions, Nvidia BlueField DPUs and Nvidia DOCA provide in-silicon zero-trust policy enforcement, runtime threat detection, and network encryption to protect AI workloads, agents, and data without performance tradeoffs

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HPE added secure local agent registration features to HPE Private Cloud AI, letting customers approve AI models, skills, and tools against centralized governance and security policies before they run

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. New HPE Zerto Software capabilities detect rogue agent actions and use continuous data protection to rewind to a clean state

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Juniper Networking Integration and Self-Driving Strategy

Following its acquisition of Juniper less than a year ago, HPE is integrating Juniper networking technology deeply into its AI Datacenter stacks

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. Rami Rahim, HPE's EVP and general manager for Networking, explained that the company is "bringing our networking portfolio to HPE AI factories and AI infrastructure" while accelerating innovation by integrating the best features from HPE MIST into HP Aruba Central

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The self-driving networking strategy now extends across campus, branch, data center, and AI infrastructure environments

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. Marvis actions are now supported in Aruba Central, while CX switches can be managed via Mist, as HPE cross-pollinates capabilities from its two AIOps platforms

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New hardware includes the Juniper QFX5140, a 16 Tbps switch built on Trident5 and aimed at inference clusters and edge AI, and the QFX5252 Switch tray for AMD Helios, a scale-up module for AMD's rack-scale AI platform

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. Rahim said problems that once took hours or days to diagnose can now be resolved in minutes or even proactively before anyone understands there is an issue

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Source: The Register

Source: The Register

Full-Stack Integration and Enhanced Capabilities

HPE AI Factory at Scale, HPE Sovereign AI Factory, and HPE Private Cloud AI are now available with Nvidia RTX PRO 6000 Blackwell Server Edition GPUs, Nvidia Spectrum-X networking, Nvidia BlueField-3 DPUs, and Nvidia ConnectX-8 SuperNICs

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. For next-generation AI factories, every Vera Rubin NVL72 system will ship with Nvidia networking built in, including Nvidia Vera BlueField-4 DPUs, Nvidia ConnectX-9 SuperNICs, and Spectrum-X Ethernet

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On the storage side, HPE Alletra Storage MP X10000 automatically applies metadata and governance policies to prepare unstructured data for AI pipelines, improving token throughput

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. The device achieved the foundation level of Nvidia-Certified Storage and will be available from July

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Russo said HPE's data fabric software will soon have integration points with agentic workloads, allowing agents to see across enterprise data whether it's in the cloud or third-party storage, with automated workflows to access that data with identity access management and security criteria

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HPE is also bringing Juniper datacenter networking into the Greenlake platform, creating a unified cross-domain operating experience across compute, storage, and networking

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. Rahim emphasized that HPE is positioning itself as a full-stack networking provider to address what he calls a fundamental architectural challenge, noting that many enterprise AI deployments fail because organizations don't think about architecture in advance

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The updates reflect HPE's belief that enterprises are entering a new phase where AI agents at scale will increasingly take actions rather than simply answer questions, creating both opportunities and challenges around governance, security, and hybrid operations

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. For IT operations teams, this signals a shift from managing infrastructure to orchestrating intelligent systems that can detect, diagnose, and remediate issues autonomously.

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