HPE expands AI infrastructure portfolio with NVIDIA to power next-generation autonomous agents

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HPE unveiled sweeping updates to its AI infrastructure at Discover Las Vegas, integrating NVIDIA's Vera CPU and Agent Toolkit into its Private Cloud AI platform. The company is positioning itself as a full-stack supplier for enterprises deploying AI agents at scale, with new self-driving networking capabilities, confidential computing protections, and enhanced data management tools designed specifically for agentic AI workloads.

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HPE Positions AI Infrastructure for the Agentic Enterprise

HPE is making a decisive move to capture the emerging market for agentic AI infrastructure, unveiling a comprehensive portfolio expansion at HPE Discover in Las Vegas that spans compute, networking, storage, and security. The company announced that its HPE AI Factory with NVIDIA now includes support for the Nvidia Vera CPU, Nvidia Agent Toolkit, and expanded Nvidia Confidential Computing capabilities across its entire lineup

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. According to HPE's EVP and CTO Fidelma Russo, the company aims to "help our customers with their transformation to an agentic AI infrastructure" as enterprises move AI agents from proof of concept to production

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The announcements reflect HPE's belief that autonomous agents represent not just another adoption curve but a fundamental technology spending shift requiring solid architectural foundations. Rami Rahim, HPE's EVP and general manager for Networking, warned that many AI projects will "fail if they are not built with the right foundation," including proper controls and operating models

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. This positions HPE as addressing critical infrastructure gaps as organizations grapple with deploying AI that doesn't just answer questions but takes autonomous actions.

NVIDIA Vera CPU Powers HPE Private Cloud AI for Agent Workloads

The HPE ProLiant Compute DL394 Gen12 server featuring the Nvidia Vera CPU will become available in 2027 as part of HPE Private Cloud AI, the turnkey platform co-engineered with NVIDIA

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. Vera represents the first CPU purpose-built for agents, designed specifically to handle the rapid tool calls, complex orchestration, and real-time data processing required across the agent loop with deterministic, low-latency performance

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. The New York Stock Exchange, collaborating with Redpanda and HPE, is already exploring early deployment of the Vera CPU with the ProLiant server.

The Vera CPU is part of the broader NVIDIA Vera Rubin platform, which is ramping into full production with the NVIDIA Vera Rubin NVL72 rack-scale system available from HPE. Built for frontier-scale models exceeding 1 trillion parameters, Vera Rubin ships with full-stack Nvidia Confidential Computing across every chip

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. HPE is also introducing the HPE Compute XD700 built on NVIDIA HGX Rubin NVL8, supporting up to 128 Rubin GPUs per rack. This hardware expansion gives enterprises the compute density needed for next-generation autonomous agents operating at scale within secure, on-premises environments.

Nvidia Agent Toolkit Delivers Agentic Operating System

HPE Private Cloud AI now includes the Nvidia Agent Toolkit, encompassing Nvidia Nemotron models, the NVIDIA OpenShell secure runtime, and NVIDIA NemoClaw blueprints

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. Together, these components provide what amounts to an agentic AI operating system for monitoring agent behavior, enforcing governance policies, and safely building and running autonomous, long-running multi-agent systems. HPE adds secure local agent registration capabilities, allowing customers to approve AI models, skills, and tools against centralized governance and security policies before deployment

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New HPE Zerto Software capabilities detect rogue agent actions and employ continuous data protection to rewind systems to a clean state when agents go off-rails

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. On the data management front, HPE Alletra Storage MP X10000—which achieved foundation-level NVIDIA-Certified Storage status—automatically applies metadata and governance policies to prepare unstructured data for AI pipelines while improving token throughput

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. These governance and security controls address the critical need for enterprises in regulated industries to maintain strict compliance while deploying autonomous agents.

Self-Driving Networking Extends Into AI Data Center Solutions

HPE is integrating its Juniper networking portfolio more deeply into HPE AI Factory offerings, bringing what Rahim calls self-driving networking capabilities into AI Data Center Solutions

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. New hardware includes the HPE Juniper Networking QFX5140 switch, a 16 Tbps device built on Trident5 and aimed at inference clusters and edge AI deployments, plus the QFX5252 Switch tray optimized for AMD's Helios rack-scale AI platform

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. These additions target the networking bottlenecks that can leave GPUs waiting for data rather than processing agentic AI workloads.

Rahim emphasized that HPE is "already leading the industry in self-driving networks" with AI for Networks capabilities that "remain years ahead of the competition"

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. The company introduced AI-based root-cause analysis for data center operations, combining telemetry, application flows, operational context, and historical knowledge to diagnose issues. "Problems that once took hours, if not days, to diagnose can now be resolved literally in minutes or even proactively before anybody understands that there is an issue," Rahim stated

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. HPE is also extending the Mist Marvis AI engine throughout infrastructure layers, with Marvis actions now supported in Aruba Central and CX switches manageable via Mist

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Confidential Computing and Full-Stack Integration Across Portfolio

Nvidia Confidential Computing is now available across all HPE AI Factory solutions—including HPE AI Factory at Scale, HPE Sovereign AI Factory, and HPE Private Cloud AI—through HPE Services

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. This addresses the critical need to protect models and private data during execution for on-premises and sovereign deployments, establishing a cryptographic chain of trust through attestation and encryption at every stage

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. The HPE ProLiant Compute DL380a achieved certification as part of the NVIDIA-Certified Systems for NVIDIA Confidential Computing program, validating robust application performance with confidential computing enabled.

All HPE AI Factory solutions now feature enhanced full-stack NVIDIA integration, available with NVIDIA RTX PRO 6000 Blackwell Server Edition GPUs, NVIDIA Spectrum-X Ethernet networking, NVIDIA BlueField-3 DPUs, and NVIDIA ConnectX-8 SuperNICs

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. For next-generation systems, every Vera Rubin NVL72 will ship with NVIDIA networking built in—NVIDIA Vera BlueField-4 DPUs, NVIDIA ConnectX-9 SuperNICs, and NVIDIA Spectrum-X Ethernet—with NVIDIA Spectrum-6 switching delivering 1.6x higher networking performance for AI communication versus standard Ethernet. HPE is also bringing datacenter networking into the Greenlake platform, creating what Rahim describes as "a unified cross-domain operating experience across compute, storage, and networking"

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. These updates position HPE to serve enterprises seeking turnkey infrastructure for hybrid operations supporting large populations of AI agents with the security, governance, and performance controls production deployments demand.

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