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New 3D imaging technique enhances basal cell carcinoma diagnosis
Agency for Science, Technology and Research (A*STAR), SingaporeApr 8 2025 Researchers from the Agency for Science, Technology and Research (A*STAR) and the National Healthcare Group (NHG) have jointly pioneered an innovative imaging technique combining Multispectral Optoacoustic Tomography (MSOT)
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Scientists pioneer noninvasive 3D imaging to enhance skin cancer management
by Agency for Science, Technology and Research (A*STAR), Singapore Researchers from the Agency for Science, Technology and Research (A*STAR) and the National Healthcare Group (NHG) have jointly pioneered an innovative imaging technique combining Multispectral Optoacoustic Tomography (MSOT) with
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Researchers from A*STAR and NHG have developed an innovative AI-powered 3D imaging technique that could significantly improve the diagnosis and treatment of basal cell carcinoma, the most common form of skin cancer.

Researchers from the Agency for Science, Technology and Research (A*STAR) and the National Healthcare Group (NHG) in Singapore have developed a groundbreaking imaging technique that combines Multispectral Optoacoustic Tomography (MSOT) with artificial intelligence to enhance the diagnosis and treatment of basal cell carcinoma (BCC), the most common form of skin cancer worldwide
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.The new technique utilizes photoacoustic imaging (PAI) enhanced by an automated segmentation algorithm to provide real-time, high-resolution, three-dimensional images of skin tumors. This AI-powered system offers several advantages over traditional diagnostic methods:
By providing clearer insights into tumor boundaries, the technology aims to minimize repeat surgeries and improve patient recovery experiences
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.BCC cases are on the rise in Singapore, particularly among the aging population. Current diagnostic methods such as biopsy and Mohs micrographic surgery can be uncomfortable and time-consuming, often requiring multiple procedures to confirm tumor extent and ensure complete removal
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.The new AI-enhanced imaging technique addresses these challenges by:
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The technology is currently undergoing testing at the National Skin Centre (NSC) in Singapore, with eight patients participating in a pilot study. Early findings from MSOT scans performed before surgery have shown strong alignment with existing diagnostic methods
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.Prof Malini Olivo, Distinguished Principal Scientist, and Assoc Prof Dinish U. S, Principal Investigator at A*STAR SRL, who are co-authors of the study, expressed optimism about the technology's potential: "Early results have been very promising, showing strong alignment with existing diagnostic methods. We are now focused on bringing this technology closer to real-world clinical use to benefit skin cancer patients"
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.While the current study focuses on basal cell carcinoma, researchers believe the technology could be adapted to detect other types of skin cancer prevalent in Singapore and the region
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.Prof Steven Thng, Deputy Director and Senior Consultant at the National Skin Centre, NHG, and co-author of the study, highlighted the potential impact on patient care: "We are very excited that our National Skin Centre is the first in the region to use reflectance confocal microscopy for diagnosis of skin cancer in place of biopsy. With this, we aim to individualise surgery for our patients, reducing mortality and morbidity for them"
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.As this AI-enhanced imaging technique continues to develop and prove its efficacy, it has the potential to revolutionize skin cancer diagnosis and treatment, offering more precise, less invasive, and more efficient care for patients worldwide.
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