ApexGO uses generative AI to optimize antibiotics, achieving 85% success against superbugs
University of Pennsylvania researchers have developed ApexGO, an AI-powered methodology that transforms imperfect antibiotic candidates into potent drugs. The system achieved 85% success in halting bacterial growth, with 72% outperforming their original templates. In preclinical mouse models, ApexGO-designed peptides matched polymyxin B, a last-resort antibiotic, marking a shift toward systematic antibiotic discovery.